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This justification is typically accom-plished by providing adequate background to embed the study in a particular context withan adequate rationale that is supported by the research literature.

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The greatest challengein the conduct of clinical trial is the eliminationof bias. The trees whose leaves imprinted upon those stones grew dur-ing and before the Jurassic period. Dementia is characterizedby a subcortical profile including deficits in attention, EF,and visuospatial abilities early in the course of cognitivedecline (Albert et al., 1974).

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